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Late Show with David Letterman

Season 13 · Episode 51

George Clooney, Ashlee Simpson

0.0November 21, 2005

Dave shocks the audience with the news that Oprah Winfrey will be a guest on the show a week from Thursday; Biff undergoes Lasek eye surgery; George Clooney promotes "Syriana."

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Episode 41Jennifer Aniston, 50 Cent
Episode 42Matthew Broderick, Teri Garr
Episode 43Kelly Ripa, Hilary Duff
Episode 44Steve Martin, the Teutul family from "American Chopper"
Episode 45Ted Koppel, Jim Gaffigan, Trey Anastasio
Episode 46Kid scientists, John Cusack
Episode 47Joaquin Phoenix, Trisha Yearwood
Episode 48Ellen DeGeneres, Brad Paisley
Episode 49Howard Stern, Pharrell Williams
Episode 50Sen. John McCain, Carla Gugino
Episode 51George Clooney, Ashlee Simpson
Episode 52Dennis Quaid, Donovan McNabb
Episode 53Stupid Pet Tricks, Claire Danes, Big Boi
Episode 54Megan Mullally, John Mayer Trio
Episode 55John Malkovich, NASCAR Nextel Cup winner, Jim Gaffigan
Episode 56Stupid Human Tricks, Amanda Peet
Episode 57Regis Philbin, Colin Hanks
Episode 58Charlize Theron, Maureen Dowd
Episode 59Oprah Winfrey, Bonnie Raitt
Episode 60Rodeo champion Billy Etbauer
Episode 61Jack Black, Reggie Bush, Sinead O'Connor
Episode 62Sarah Jessica Parker, John Witherspoon
Episode 63Stephen Colbert, Aqualung
Episode 64Alec Baldwin, Shakira
Episode 65Dr. Phil McGraw, Bill Scheft
Episode 66Jim Carrey, We Are Scientists
Episode 67Bonnie Hunt, Stephen A. Smith
Episode 68Nathan Lane, Tom Dreesen
Episode 69Jamie Foxx, Andy Kindler
Episode 70Rosie Perez, Jay Thomas, Darlene Love
Episode 71Heather Graham, Fall Out Boy
Episode 72Bill O'Reilly, Eric Bana
Episode 73Pierce Brosnan, Marv Albert
Episode 74Felicity Huffman, David Rakoff, Common
Episode 75Amy Sedaris, Dennis Regan, the Temptations
Episode 76Albert Brooks, Kristin Cavallari
Episode 77Scarlett Johannsen, Tiki Barber, Imogen Heap
Episode 78Queen Latifah, Bob Sarlatte
Episode 79Kiefer Sutherland, Alicia Keys, Andy Samberg
Episode 80Tom Cavanagh, Jake Johannsen
Episode 81Martin Lawrence, Kari Byron, Matisyahu
Episode 82Tatum O'Neal, Jeff MacGregor
Episode 83Kate Beckinsale, Bob Saget
Episode 84Cheryl Hines, Anna Nalick, Mike Vanderjagt
Episode 85Charles Grodin, Jordana Brewster
Episode 86Anthony Hopkins
Episode 87Bernie Mac, Beth Orton
Episode 88Mischa Barton, Jeff Altman, Wicked Wisdom
Episode 89Tommy Lee Jones, Anthony Hamilton
Episode 90P Diddy, Train
Episode 91Harrison Ford, Michael Bublé
Episode 92Beyonce Knowles, Stephen A. Smith
Episode 93Rachel Weisz, Beastie Boys
Episode 94Senator John McCain, Heidi Klum
Episode 95Martha Stewart, Michael Bublé
Episode 96Geena Davis, INXS
Episode 97Julianne Moore, Randy Jackson, The O'Jays
Episode 98Charles Barkley, Catherine Keener
Episode 99Jimmy Fallon, Hannah Teter, She Wants Revenge
Episode 100Donald Trump, Bill Burr
Episode 101Marcia Cross, Daytona 500 Winner
Episode 102Matthew Fox, Brian Regan, Broadway's Jersey Boys
Episode 103Philip Seymour Hoffman, The Teutuls
Episode 104Amanda Peet, Jack Hanna
Episode 105Hugh Laurie, Ne-Yo
Episode 106Bruce Willis, The Strokes
Episode 107Barbara Walters, Tyler James Williams
Episode 108Sarah Jessica Parker
Episode 109Harry Connick Jr., Clap Your Hands Say Yeah
Episode 110Ricky Gervais, The Subways
Episode 111Emma Thompson, Frank Caliendo, Beth Orton
Episode 112Howard Stern, Carrie Underwood
Episode 113Natalie Portman, Al Franken
Episode 114Vin Diesel, Trey Parker & Matt Stone
Episode 115Denzel Washington, Diablo Cody
Episode 116Marcia Cross, Jenny Lewis and the Watson Twins
Episode 117David Spade, Teddy Geiger
Episode 118Sharon Stone, Mark Fainaru-Wada, Lance Williams
Episode 119Ray Romano, Willie Nelson
Episode 120Josh Hartnett, Chris Elliott, Yeah Yeah Yeahs
Episode 121Antonio Banderas, Patrice Oneal, Flaming Lips
Episode 122Liza Minnelli, Al Lubel
Episode 123Billy Crystal, Johnny Damon
Episode 124Geena Davis, Aaron Eckhart, Sonya Kitchell
Episode 125Jason Randal, Mandy Moore, Ben Harper
Episode 126Julia Louis-Dreyfus, Tyler Perry, Death Cab For Cutie
Episode 127Paul Rudd, Gretchen Mol, Mary J. Blige
Episode 128Eva Longoria, Barry Sonnenfeld
Episode 129Jane Fonda, Shooter Jennings
Episode 130Craig Furguson, Alexis Bledel, Tom Russell
Episode 131Piedmont Bird Callers, Michael Douglas, Emmylou Harris, Mark Knopfler
Episode 132Kerri Russell, Jerry Lee Lewis, Human Cannonball Team
Episode 133Tom Hanks, Kanye West
Episode 134Tom Cruise, Jamie Oliver
Episode 135Rosie Perez, Danica Patrick
Episode 136Julia Roberts, Pearl Jam
Episode 137Vince Vaughn, K.T. Tunstall
Episode 138Derek Jeter, Michelle Monghan, Barnum & Bailey Circus
Episode 139Kurt Russell, The Little Willies
Episode 140Jason Lee, Jack Hanna
Episode 141Teri Hatcher, Tom Dreesen, Michel Lauziere
Episode 142Edie Falco, Pete Correale, Van Hunt
Episode 143Kid Scientists, William Shatner, Angels & Airwaves
Episode 144Debra Messing, Chris Russo
Episode 145Bruce Willis, Goldfrapp
Episode 146Stupid Pet Tricks, Rebecca Romijn, Eagles of Death Metal
Episode 147Jennifer Garner, Harry Hill
Episode 148Martha Stewart, Dixie Chicks, Criss Angel
Episode 149Martin Short, James Blunt
Episode 150Jennifer Aniston, Rob Zombie
Episode 151Halle Berry, Harold Perrineau, Jesse James
Episode 152Bill Maher, Rita Wilson
Episode 153Lindsay Lohan, Sam Hornish Jr.
Episode 154Bonnie Hunt, Elvis Costello, Allen Toussaint
Episode 155Kyra Sedgwick, Al Franken
Episode 156Meredith Vieira, Jeremy Piven, My Morning Jacket
Episode 157Michael Keaton, Wolfmother
Episode 158Paris Hilton, Will Shortz
Episode 159Tim Russert, Cat Power
Episode 160Stephen Colbert, Mark Cuban, Neko Case
Episode 161Sandra Bullock, Widespread Panic
Episode 162Robert Duvall, Tommy Tiernan, Sonic Youth
Episode 163Adam Sandler, Julie Chen
Episode 164Nicole Richie, Brandon Routh
Episode 165Dwyane Wade, Amy Sedaris, Morningwood
Episode 166Meryl Streep, Yellowcard
Episode 167Al Gore, Rock Kills Kid
Episode 168Kevin Spacey, The Streets
Episode 169Anne Hathaway, Jim Gaffigan, Dashboard Confessional
Episode 170Robert Downey Jr., Fred Willard, Martha Wainwright
Episode 171Johnny Depp, Broken Social Scene
Episode 172Tom Brokaw, Paul Simon
Episode 173John Witherspoon, The Fray
Episode 174Paul Reubens, Yunjin Kim, Nelly Furtado
Episode 175Denis Leary, New York Met David Wright, the Wreckers
Episode 176Luke Wilson, Band of Horses
Episode 177Anderson Cooper, Greg Fitzsimmons
Episode 178Kate Hudson, Patrice O'Neal
Episode 179Regis Philbin, Bryce Dallas Howard
Episode 180Uma Thurman, Morgan Spurlock, egg catchers Brad Freeman and Patrick Breault
Episode 181Martin Short, Pink
Episode 182Donald Trump, Nick Griffin, Sam Roberts
Episode 183Colin Farrell, India.Arie
Episode 184Greg Kinnear, reptile expert Dr. Darrel Frost, Tapes 'n Tapes
Episode 185Scarlett Johansson, Paul Teutul Jr. and Sr.
Episode 186Johnny Depp, the Spinners
Episode 187Jamie Foxx, Tom Dreesen
Episode 188Samuel L. Jackson, Gnarls Barkley
Episode 189Hilary Duff, Jason Randal, Dirty Pretty Things
Episode 190Jessica Biel, Christina Aguilera
Episode 191Whoopi Goldberg, sock puppeteer Jack Fisett, Fatboy Slim
Episode 192Edward Norton, Greg Fitzsimmons
Episode 193Julianna Margulies, Andy Sansone, Outkast
Episode 194Chris Elliott, Rep. Nancy Pelosi, Razorlight
Episode 195John McEnroe, Artie Lang, Busta Rhymes
Episode 196Mark Wahlberg, Ruth Regina, M. Ward
Episode 197Maggie Gyllenhaal, Albert Pujols