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Watch What Happens Live with Andy Cohen
Season 22 · Episode 149
Kyle MacLachlan, Sherri Shepherd
0.021mSeptember 22, 2025
Andy Cohen interviews Sherri Sheperd and Kyle MacLachlan.
Episodes
- Episode 1Diana Cruz, Danni Warren
- Episode 2Erika Jayne, Racquel Chevremont
- Episode 3Dorinda Medley, Whitney Rose
- Episode 4Glenn Close
- Episode 5Ana Ortiz, Ashley Darby
- Episode 6Robbie Williams, Julia Stiles
- Episode 7Sai De Silva, Erin Lichy
- Episode 8Chrishell Stause, Lisa Barlow
- Episode 9Patricia Arquette, Gwendoline Christie
- Episode 10Keke Palmer, Dr. Wendy Osefo
- Episode 11Keith Allen, Mekki Leeper
- Episode 12Bozoma Saint John, Jenna Lyons
- Episode 13Julia Fox, Bronwyn Newport
- Episode 14TJ Dinch, Taylor Ann Green
- Episode 15Quad Webb, Mia Thornton
- Episode 16Daisy Kelliher, Aesha Scott
- Episode 17Garcelle Beauvais, Bob Harper
- Episode 18Chloe Fineman, Mary Cosby
- Episode 19Austen Kroll, Patricia Altschul
- Episode 20Gizelle Bryant, Robyn Dixon
- Episode 21Capt. Jason Chambers, Tzarina Mace-Ralph
- Episode 22Kyle Richards, Harry Hamlin
- Episode 23Drew Barrymore, Nate Burleson
- Episode 24Maddi Reese, Craig Conover
- Episode 25Amy Schumer, Brianne Howey
- Episode 26The Women of Saturday Night Live
- Episode 27Lindsay Hubbard, Ciara Miller
- Episode 28Anya Taylor-Joy, Miles Teller
- Episode 29Dr. Contessa Metcalfe, Lateasha Lunceford
- Episode 30Jon Hamm, Morris Chestnut
- Episode 31Jennifer Tilly, Crystal Kung Minkoff
- Episode 32Dolores Catania, Carl Radke
- Episode 33Michols Peña, Salley Carson
- Episode 34Stacey Rusch, Dr. Simone Whitmore
- Episode 35Gabrielle Union, Jay Ellis
- Episode 36Denise Richards, Sutton Stracke
- Episode 37Kyle Cooke, Tom Sandoval
- Episode 38Southern Hospitality Season 3 Reunion
- Episode 39Porsha Williams, Law Roach
- Episode 40Adair Werley, Michelle Collins
- Episode 41Dorit Kemsley, Gabby Windey, Dylan Efron
- Episode 42Liza Treyger, West Wilson
- Episode 43Anitta, Uzo Aduba
- Episode 44Shamea Morton, Toya Bush-Harris
- Episode 45Chrissy Teigen, Harry Van Vliet
- Episode 46Leslie Bibb, Garcelle Beauvais
- Episode 47Ciara Miller, Amanda Batula
- Episode 48Annaleigh Ashford, Venita Aspen
- Episode 49Will Packer, Angela Oakley
- Episode 50Debra Messing, Ellen Pompeo
- Episode 51Erika Jayne, Bozoma Saint John
- Episode 52Imrul Hassan, Jesse Solomon
- Episode 53Craig Conover, Shep Rose, Austen Kroll
- Episode 54Kelli Ferrell, Michelle Buteau
- Episode 55Bill Murray, Naomi Watts
- Episode 56Kathryn Hahn, Ike Barinholtz, Chase Sui Wonders
- Episode 57Carl Radke, Madison Lecroy
- Episode 58Michelle Williams, John Oliver
- Episode 59Cynthia Bailey, Danielle Brooks
- Episode 60Lara Rigby, Mzi Dempers
- Episode 61Elisabeth Moss, Maren Morris
- Episode 62Lexi Wood, Danielle Schneider
- Episode 63Anthony Anderson, Matthew Rhys
- Episode 64Mark Indelicato, Brit Eady
- Episode 65Brianna Duffield, Marina Marcondes
- Episode 66Kristen Doute, Nia Sanchez Booko
- Episode 67Casey Wilson, Paige Desorbo
- Episode 68Kristen Kish, Gail Simmons, Tom Colicchio
- Episode 69Gizelle Bryant, Porsha Williams
- Episode 70Eva Longoria, Sandra Bernhard
- Episode 71Brittany Cartwright, Luke Broderick
- Episode 72Ciara Miller, Madeline Brewer
- Episode 73Lisa Vanderpump
- Episode 74Elizabeth Perkins, Luann de Lesseps
- Episode 75Connie Britton, Will Forte
- Episode 76Zack Wickham, Michelle Saniei
- Episode 77Tinx, Lexi Wood
- Episode 78John Benjamin Hickey, Patricia Clarkson
- Episode 79Ariana Madix, Shamea Morton
- Episode 80Melissa Rivers, Nate Salmon
- Episode 81Jesse Lally, Danny Booko
- Episode 82West Wilson, Jesse Solomon
- Episode 83Snoop Dogg, Lizzo
- Episode 84Ashley Darby, Kelli Ferrell
- Episode 85Harry Van Vliet, Nicolas Cattelan
- Episode 86Janet Caperna, Jason Caperna
- Episode 87Lindsay Hubbard, Kyle Cooke
- Episode 88Elizabeth Banks, Amanda Peet
- Episode 89La La Anthony, Phaedra Parks
- Episode 90Capt. Kerry Titheradge, Hannah Ferrier
- Episode 91Jasmine Goode, Yvonne Strahovski
- Episode 92Amanda Batula, Kristin Cavallari
- Episode 93Hoda Kotb, Mario Cantone
- Episode 94Shannon Storms Beador, Drew Sidora
- Episode 95Scott Porter, Fraser Olender
- Episode 96Bryce Dallas Howard, Michelle Saniei
- Episode 97Cynthia Nixon, Ricki Lake
- Episode 98Luann du Lesseps, Joel Kim Booster
- Episode 99Rainbeau de Roos, Anthony Iracane
- Episode 100Tom Schwartz, Jax Taylor
- Episode 101Alexia Nepola, Marysol Patton
- Episode 102Ciara, Anthony Ramos
- Episode 103Angela Oakley, Cynthia Bailey
- Episode 104Arnold Schwarzenegger
- Episode 105Haim
- Episode 106Kiki Barth, Larsa Pippen
- Episode 107Charlize Theron, Henry Golding
- Episode 108Phaedra Parks, Ariana Biermann
- Episode 109Barbara Kulaif, Damo Yorg
- Episode 110Abby Elliott, Jesse Lally
- Episode 111Stephanie Shojaee, Sara Foster
- Episode 112Tamra Judge, Steven McBee Jr.
- Episode 113Sarah Jessica Parker
- Episode 114Amy Sedaris, Dan Levy
- Episode 115Riley Burruss, Kandi Burruss
- Episode 116Lisa Hochstein, Rebecca Romijn
- Episode 117Emily Simpson, Leah Kateb
- Episode 118Tyson Beckford, Octavia Spencer
- Episode 119Meg Stalter, Tracee Ellis Ross
- Episode 120Brittany Cartwright, Zack Wickham
- Episode 121Guerdy Abraira, Tommy Dorfman
- Episode 122Shannon Storms Beador, Denise Welch
- Episode 123Kristen Johnson, Leanne Morgan
- Episode 124Jess Theron, Hugo Ortega
- Episode 125Gia Giudice, Brooks Marks, Emira D'Spain
- Episode 126Julia Lemigova, Isaac Mizrahi
- Episode 127Katie Ginella, Kim Zolciak
- Episode 128Pamela Anderson, Liam Neeson
- Episode 129Bowen Yang, Matt Rogers
- Episode 130Alison Brie, Dave Franco
- Episode 131Adriana De Moura, Loni Love
- Episode 132Gina Kirschenheiter, Julia Garner
- Episode 133MGK, Pamela Adlon
- Episode 134Kyle Stillie, Fraser Olender
- Episode 135Seth Rogen, Rose Byrne, Luke Macfarlane
- Episode 136Amaya Espinal, Bryan Arenales, Olandria Carthen, Nic Vansteenberghe
- Episode 137Heather Dubrow, Kaylor Martin
- Episode 138Sharon Stone, Bob Odenkirk
- Episode 139Anthony Iracane, Barbara Kulaif
- Episode 140Ashlee Simpson Ross, Dylan O'Brien
- Episode 141Michelle Williams, Joy Behar
- Episode 142Jennifer Pedranti, Alexia Nepola
- Episode 143Chaka Khan, Patti LaBelle, Stephanie Mills
- Episode 144Capt. Kerry Titheradge, Michelle Collins
- Episode 145Angie Katsanevas, Demi Lovato
- Episode 146Mark Ronson, Brooks Nader
- Episode 147Gretchen Rossi, Larsa Pippen
- Episode 148Tom Blyth, Russell Tovey
- Episode 149Kyle MacLachlan, Sherri Shepherd
- Episode 150Madelaine Petsch, Bronwyn Newport
- Episode 151Teyana Taylor, Ego Nwodim
- Episode 152Adriana de Moura, Tamra Judge
- Episode 153Jesse Williams, Regina Hall
- Episode 154Aesha Scott, Victoria Sanjuan
- Episode 155Lisa Barlow and Sean Avery
- Episode 156Mariah Carey
- Episode 157Jimmy Fallon, Bozoma Saint John
- Episode 158Latto, Gizelle Bryant
- Episode 159Captain Sandy Yawn, Nathan Gallagher
- Episode 160Adam Pally, Mary Cosby
- Episode 161Julia Roberts
- Episode 162Bridget Everett, Heather Dubrow
- Episode 163Jeff Lewis, Ashley Darby
- Episode 164Jennifer Hudson, Laverne Cox
- Episode 165Lukas Gage, Whitney Rose
- Episode 166Jennifer Lopez
- Episode 167Bette Midler
- Episode 168Keiarna Stewart, Phoebe Robinson
- Episode 169Kizzi Kitchener, Josh Bingham
- Episode 170Meredith Marks, Allison Williams
- Episode 171Allison Janney, Keri Russell
- Episode 172Shannon Storms Beador, Garcelle Beauvais
- Episode 173Lauren Smith, Mariah Smith, Rachel Smith, Stacey Rusch
- Episode 174Captain Sandy Yawn, Joe Bradley
- Episode 175Erin Lichy, Lisa Barlow
- Episode 176Tessa Thompson, Justine Lupe
- Episode 177Chrishell Stause, Gina Kirschenheiter
- Episode 178Karamo and Tia Glover
- Episode 179Isla Fisher and Judd Apatow
- Episode 180Sarah Paulson and Bronwyn Newport
- Episode 181Janelle James and Jerrod Carmichael
- Episode 182Brittany Snow and Dakota Fanning
- Episode 183Danielle Schneider and Angel Massie
- Episode 184Captain Jason Chambers and Daisy Kelliher
- Episode 185Heather Gay and Ricki Lake
- Episode 186Tiffany Haddish and Gayle King
- Episode 187Patti Lupone and Anderson Cooper
- Episode 188Max Salvador and Victoria Sanjuan
- Episode 189Britani Bateman, Marcus Johnson and Natalie Maguire
- Episode 190Madison LeCroy and Austen Kroll
- Episode 191Rep. Robert Garcia and Kyle Richards
- Episode 192Monique Samuels and Sarah Sherman
- Episode 193Mickey Guyton and Joe Bradley
- Episode 194Heather Gay and Matt Rogers
- Episode 195Shep Rose and Molly O'Connell
- Episode 196Dorit Kemsley and Zooey Deschanel
- Episode 197Dr. Simone Whitmore and Keiarna Stewart
- Episode 198Victoria Beckham and Kerry Washington
- Episode 199Meredith Marks and Noah Schnapp
- Episode 200S.E. Cupp and Craig Conover
- Episode 201Erika Jayne and Brooks Nader
- Episode 202Ashley Darby & Toya Bush-Harris
- Episode 203Kate Hudson and Ice Spice